Just as she's set to go on a 42-city tour, comedian Amy Schumer learns she's pregnant with her first child. She is over the moon! As Amy works to perfect her most personal comedy special yet, she and her husband Chris begin to grow concerned as her golden second trimester still finds her violently throwing up daily. With the night of her special's taping fast-approaching, things take a scary turn.

After checking into the ER, Amy receives a diagnosis that gives her more insight into her hellish pregnancy, but also requires her to reschedule the taping of her special. As the new date looms, Amy and Chris reflect on their relationship and notice a concerning pattern of communication issues, prompting Chris to seek out a diagnosis of his own.

A 23-weeks-pregnant Amy takes the stage in Chicago to film her special (and hopefully not throw up in front of a fully packed house). After her deeply intimate set is finally captured on film, she and Chris can shift their focus to parenthood, but their excitement quickly turns to anxiety when they learn of another possible complication. At long last, Amy gives birth to her new son, Gene.