When a rancher is murdered, John Henry Hoyle, the new Sheriff, uses all of his Harvard trained state-of-the-art criminology training to solve the crime.

When Frank James attempts to rob the Great Bend Bank, Hoyle and Eli save the day and jail the famous outlaw.

Much to Hoyle's chagrin, Eli purchases a mail order bride, but when the coach arrives with Eli's precious cargo, its contents send the duo into an unexpected tailspin.

In the wake of a gruesome decapitation, Hoyle uses the latest in crime-fighting techniques to apprehend the killer, but when the evidence points in an unexpected direction, Hoyle must persuade the town to listen to science.

The Temperance movement takes hold in Great Bend after a slew of alcohol-related deaths. However, when the saloon goes booze free, Honey resorts to selling “medicine” to keep the bar in business.

When the U.S. Marshalls unfairly suspect an ex-slave of murder, Sheriff Hoyle must clear his name by tracking the real killer to the all-black town of Nicodemus, led by Sheriff Nat Love.

When Honey’s long-lost fiancé surfaces in Great Bend, he challenges Hoyle to a duel when he learns of their ongoing “relations.” Meanwhile, things start to get more serious between Eli and Pearl.

After a group of local miscreants turns up dead, Hoyle, Eli, Honey and the gang track the killers to Cole Younger’s hideout, giving Hoyle another shot at finally bringing Cole to justice.