In March 2000, 71-year-old Margarita Ruiz and her adult daughter Hope are senselessly murdered. Detectives and relatives are stunned and the case goes unsolved for six years. Then, fortuitously, a puzzling phone call from 1500 miles away leads investigators to the killer.

A young wife and mother is brutally murdered in her own home, and her family shot and left for dead.

A Philadelphia mother is murdered at home, execution-style- right before her child's eyes. The hunt for her killer leads to a maddening series of dead ends until months later, when the case breaks in an astonishing direction.

A late night encounter leads to the horrific murder of a young Birmingham woman, igniting a sense of panic throughout the city. A man offering information in the form of mystical visions helps guide detectives to the killer.

A woman and her 5-year-old son are brutally murdered in a field outside Dallas. A critical piece of evidence found at the scene sends one detective on a 20-year-long hunt for the killer.

Cindy Monkman Apelt is found murdered in the Arizona desert on Christmas Eve after being reported missing by her husband. Anna-Sigga Nicolazzi revisits the crime with the detectives and state attorney who solved the case.