Shuuichi Nitori is a boy who wants to be a girl and Yoshino Takatsuki is a girl who wants to be a boy. They meet in grammar school and learn one another's secrets. They become able to confide in each other as they grow up.

Yoshino and Saori have started their new lives in middle school. Things continue to be awkward as they go through their day to day. They join the various teams at the start of the semester; Yoshino to basketball and Saori to volleyball.

Per Saori's suggestion, the class decides to do a gender bender play for the upcoming cultural festival.

Shuichi starts to grow concerned about Yoshino, who has been spacing out recently.

As the gang come over to Saori's house to work on the script, Saori reveals to Makoto that she intends to enter the running for the role of Romeo.

The cultural festival is underway, with some commotion caused when Anna brings popular model Maico, who Maho works with, to the event.

Both Shuichi and Saori get scouted for the drama club, with Saori still expressing her hatred for Yoshino.

A new school year starts, with the group split into separate classes.

Having previously checked with Anna if it was okay to hang around Shuichi, Yoshino decides to wear a male uniform to school, much to the surprise of the other students and teachers.

Following the incident, Shuichi feels frustrated that they were treated differently from the times Chizuru and Yoshino came to school dressed opposite of their birth gender.

Once more, barbs and insults are exchanged when Yoshino and Saori meet. And despite animosity between Shuichi and Doi, Doi is asked to help write the script for the cultural festival play.